
Worldwide Healthcare Trust PLC Annual Report for the year ended 31 March 2026
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Apellis Pharmaceuticals, a Massachusetts-based
commercial stage biotechnology company rounds out the
prominent M&A theme that has characterised much of
the performance of the portfolio over the past 12 months,
contributing +164 basis points to NAV performance. On
the final trading day of the financial year, 31 March 2026,
Biogen announced a definitive agreement to acquire Apellis
for U.S.$41.00 per share in cash, an impressive 140%
premium to the prior day’s closing price, equating to an
upfront equity valuation of approximately U.S.$5.6 billion.
Apellis is an undisputed pioneer in targeted C3 complement
therapies. Its flagship asset, Syfovre (pegcetacoplan), is
the first and only FDA-approved treatment for geographic
atrophy, a devastating and irreversible cause of blindness.
The company also markets Empaveli for the treatment of
paroxysmal nocturnal hemoglobinuria (PNH).
MAJOR DETRACTORS TO PERFORMANCE
MedTech stock, Boston Scientific, was the portfolio’s single
largest detractor in the financial year, detracting -421 basis
points to NAV performance. After a multi-year re-rating
in which the company’s share price tripled from 2022 and
reached an all-time high on 9 September 2025, the company
finally stumbled. Share price weakness began in earnest in
the second half of the year. Positive drug pricing news at the
end of September triggered a rotation into Pharmaceuticals
from MedTech. A mix of profit taking, momentum shift,
and investor concern about share loss in the multi-billion
dollar ablation business pushed the share price down
even further. In January, the stock fell lower still after the
company reported fourth quarter financials. Of note was a
modest but clear revenue miss for the company’s key new
product, Farapulse (for the treatment of atrial fibrillation).
The unexpected miss startled investors and significantly
hurt management credibility, whilst share price pressure
was exacerbated by macro concerns (continued rotation
into pharma, lower healthcare utilisation trends, and rising
geopolitical concerns). Share price declines continued into
the year end, gapping down one more time in late March
after investor questions arose over the CHAMPION data set,
a clinical trial demonstrating the use of the WATCHMAN
implantable device (compared to oral anticoagulants) used
to prevent strokes in patients afflicted with atrial fibrillation.
Whilst we reduced our holding in Boston Scientific on
multiple occasions in the second half (and to Medical
Technology by >1000 basis points over the year), the stock
remains a prominent holding in the portfolio given our view
that the distressed valuation expresses investor fear rather
than quality management and a still robust growth outlook
fuelled by innovation.
The managed care titan, UnitedHealth, was the
second-largest detractor in the financial year, detracting
-340basis points to NAV performance. Overall, the
confluence of soaring costs, shrinking patient enrolment,
a massive cyber attack in the previous year, and a difficult
government rate-setting environment caused a structural
de-rating of the company’s valuation, dragging down the
entire services subsector. Unfortunately, UnitedHealth’s
share price in April 2025 marked the high. The company
stumbled out of the gate after missing quarterly earnings and
significantly lowering its 2025 outlook. The company cited
higher-than-expected medical costs in its Medicare business,
an issue that has affected the entire industry over the past
year. Unfortunately, the utilisation trends in healthcare
were trending higher than the company expected, severely
impacting profits. News of the CEO resigning and subsequent
headlines of a Department of Justice investigation into fraud
practices pushed the stock lower. Additional purchases at that
time proved premature as the stock eventually reached 52-
week lows in August. We ultimately exited the stock before
financial year end. Whilst absolute detraction was significant,
approaching -350 basis points, the impact on relative return
was de minimis (-6 basis points).
Daiichi-Sankyo, the global Japanese pharmaceutical
company, remains a leader in antibody-drug conjugate
technology and has been central to the development of both
Enhertu and Datroway in partnership with AstraZeneca.
However, Daiichi Sankyo’s share price was more sensitive
to Datroway-related setbacks than AstraZeneca’s because
the antibody-drug conjugate platform represents a larger
proportion of Daiichi Sankyo’s investment case. For
AstraZeneca, Datroway was one of many growth drivers
across a broad global portfolio; for Daiichi Sankyo, delays
and uncertainty around Datroway had a more direct impact
on investor confidence in the depth, timing, and profitability
of the company’s next wave of growth. During the year,
investor expectations for Datroway were affected by clinical
trial design complexity, evolving biomarker requirements,
and delays to key readouts. This has weighed heavily on the
share price, detracting -80 basis points to NAV performance.
Meanwhile, investor concerns have also increased after a
complete turnover of the management and subsequent
concerns over profitability and increased R&D spending by
the new CEO and CFO. Furthermore, broader macroeconomic
pressures and intense volatility in the Japanese yen prompted
investors to liquidate Japanese equities, regardless of
underlying corporate fundamentals.
Of the many Boston-based biotechnology companies, Vertex
Pharmaceuticals has been one of the most successful
and innovative companies from that regional hotbed. The
company delivered exceptional full-year 2025 revenue of
PORTFOLIO MANAGER’S REVIEW CONTINUED